Hydrochloric Acid → HCID 86762253, compound

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Reaction Steps

To a stirred clear colorless solution of the [(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-6-(pyrimidin-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-amine (318 mg, 948 μmol) in diethyl ether (10 mL) and dichloromethane (10 mL) is added a solution of 1 M HCl in diethyl ether (1.05 mL, 1.05 mmol). The resulting white mixture is stirred for a few minutes, then the solid is collected and washed with diethyl ether (15 mL), to give the title compound (325 mg, 92%) as a white solid. ES/MS (m/e): 336.0 (M+H).

Provenance & Evidence