Ammonia → HCID 24951785, compound

HRID 1619076Notes

Reaction equation

HRID 1619076 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:14]2[O:15][C:16](=[O:25])[C:17]3[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:18]=3[N:19]=2)[N:5]([C:7]2[C:12]([Cl:13])=[CH:11][CH:10]=[CH:9][N:8]=2)[N:6]=1.[NH3:26]>O>[C:16]([C:17]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:18]=1[NH:19][C:14]([C:4]1[N:5]([C:7]2[C:12]([Cl:13])=[CH:11][CH:10]=[CH:9][N:8]=2)[N:6]=[C:2]([Br:1])[CH:3]=1)=[O:15])(=[O:25])[NH2:26]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66813836HCID 66813836, compound

Product 1

HCID 24951785HCID 24951785, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.00 g 2-[5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazol-3-yl]-8-methyl-benzo[d][1,3]oxazin-4-one was taken up in 10 ml of a 25% ammonia solution in water and stirred for 72 h. The solids were filtered and washed with cold water to yield 0.80 g of the amide.

Workup

  1. filtrationThe solids were filtered
  2. washwashed with cold water

Sources & evidence

ORD record
ord-b6ccadd6d2f24cffae84edead778774a
Source dataset
uspto-grants-2014_07
Patent number
US08772289B2

Reaction notes

Loading…