Ethanol → 5-{2-[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-ethyl-1H-pyrrole-3-carboxylic acid

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Reaction Steps

5-{2-[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (160 mg, 0.355 mmol) was suspended in ethanol (13 mL) and treated with a 1.5 M solution of potassium hydroxide in ethanol (2.4 mL, 10 eq.) at reflux temperature for 3 hour. Solvent was evaporated to dryness and the residue dissolved in water. After treatment with acetic acid and the resulting precipitate was collected by filtration to give the title compound (150 mg, 100% yield) as a white solid.

Provenance & Evidence