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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1619092Generated: October 30, 2026

Water → HCID 46917644, compound

https://huagongshe.com/reaction/1619092

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantHCID 46917642HCID 46917642—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
ProductHCID 46917644HCID 46917644100%

Reaction Steps

To a solution of 4-{4-[4-(2,6-Diethyl-phenylcarbamoyl)-1-methyl-1H-pyrrol-2-yl]-5-methyl-pyrimidin-2-ylamino}-3-methyl-benzoic acid tert-butyl ester (438 mg, 0.790 mmol) in dichloromethane (20 ml), trifluoroacetic acid (1.2 ml) was added. The mixture was stirred at room temperature overnight. Water was added and the mixture extracted with ethylacetate. The organic solvent evaporated to dryness to give 393 mg of the title compound in quantitative yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08772280B2
Source datasetuspto-grants-2014_07
ORD IDord-13aa28ca503a4d6dbdb036805dcdb4ad
Source noteuspto-grants-2014_07