Cyclopropanecarbohydrazide → HCID 178425639, compound

HRID 1619139Notes

Reaction equation

HRID 1619139 reaction equation
[CH:1]1([C:4]([NH:6][NH2:7])=[O:5])[CH2:3][CH2:2]1.[I:8][C:9]1[CH:10]=[C:11]([CH:17]=[CH:18][C:19]=1[CH3:20])[C:12](=[NH:16])OCC>CO>[NH:16]=[C:12]([C:11]1[CH:17]=[CH:18][C:19]([CH3:20])=[C:9]([I:8])[CH:10]=1)[NH:7][NH:6][C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:5]

Participants

4

Reactant 2

HCID 81396CyclopropanecarbohydrazideHCID 58170479HCID 58170479, compound

Product 1

HCID 178425639HCID 178425639, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
75 °C

Procedure

Cyclopropanecarbohydrazide (0.36 g, 2.7 mmol) was added to a stirred solution of ethyl 3-iodo-4-methylbenzimidate (preparation 51b, 0.70 g, 2.4 mmol) in methanol (6 mL) and the mixture was stirred at 75° C. After 1.5 hours, the mixture was cooled to give a suspension. Methanol was added to the suspension and the precipitate was filtered and dried to give the desired compound in quantitative yield. The crude material was used without further purification.

Workup

  1. temperaturethe mixture was cooled
  2. customto give a suspension
  3. filtrationthe precipitate was filtered
  4. customdried

Sources & evidence

ORD record
ord-7abadc29c798475d844cf94b09445a91
Source dataset
uspto-grants-2014_07
Patent number
US08772288B2

Reaction notes

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