Boron tribromide → HCID 140584041, compound

Participants

Reaction Steps

To a solution of 0.5 g (2.0 mmol) of (E)-1-(4-methoxy-2,5-dimethylphenyl)ethanone-propyloxime obtained in Step 4 in 15 mL of dichloromethane was added boron tribromide (BBr3) (0.28 mL, 2.9 mmol) and the reaction mixture was allowed to react at room temperature with stirring. After completion of the reaction, the residue was stirred in water (20 mL) and the aqueous layer was extracted twice with 20 mL of dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and concentrated in a vacuum and the concentrate was purified by silica gel chromatography to afford 0.23 g of (E)-1-(4-hydroxy-2,5-dimethylphenyl)ethanone propyloxime as a white oil (yield: 49%).

Provenance & Evidence