反应详情

In 10 mL of dichloromethane, 0.15 g (0.39 mmol) of (E)-methyl 2-(2-((4-(1-hydroxypropyl)-2,5-dimethylphenoxy)methyl)phenyl)-3-methoxyacrylate obtained in Step 2 was reacted with 0.29 g (0.78 mmol) of pyridinium dichromate at room temperature for 2 hours with stirring, followed by filtration through celite. The organic layer was dried over anhydrous magnesium sulfate and filtered after which the solvent was removed by concentration in a vacuum. (E)-methyl 2-(2-((2,5-dimethyl-4-propionylphenoxy)methyl)phenyl)-3-methoxyacrylate was obtained as a brown oil (0.11 g, yield: 71%).

1. filtrationfollowed by filtration through celite
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. filtrationfiltered after which the solvent
4. customwas removed by concentration in a vacuum