Sodium Methoxide → HCID 67955922, compound

Participants

Reaction Steps

In 30 mL of methanol, 0.4 g (2.0 mmol) 2-chloro-1-(4-hydroxy-2,5-dimethylphenyl)ethanone was reacted with 0.40 g (7.55 mmol) sodium methoxide at room temperature for 5 hours with stirring, and the solvent was removed at a reduced pressure. To the residue was added 20 mL of water, followed by adjusting the pH to 7 with conc. HCl. The aqueous layer was extracted twice with 3 mL of dichloromethane and the organic layer was dried over anhydrous magnesium sulfate and concentrated at a reduced pressure to afford a yellowish solid compound 1-(4-hydroxy-2,5-dimethylphenyl)-2-methoxyethanone (0.30 g, yield: 78%).

Provenance & Evidence