Potassium Carbonate → HCID 67955390, compound

Participants

Reaction Steps

In 30 mL of acetonitrile (CH3CN), 0.3 g (1.55 mmol) of 1-(4-hydroxy-2,5-dimethylphenyl)-2-methoxyethanone obtained in Step 1 was reacted for 4 hours with 0.44 g (1.55 mmol) of (E)-methyl 2-(2-(bromomethyl)phenyl)-3-methoxyacrylate in the presence of 20.45 g (2.1 eq) of potassium carbonate under reflux. After completion of the reaction, the solvent was removed at a reduced pressure and the residue was stirred in water (30 mL) and extracted twice with 30 mL of dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and concentrated in a vacuum, followed by purification with silica gel to afford 0.47 g of (E)-methyl 3-methoxy-2-(2-((4-(2-methoxyacetyl)-2,5-dimethylphenoxy)methyl)phenyl)acrylate as a white solid (yield: 76%).

Provenance & Evidence