Methylhydroxylamine → HCID 67954883, compound

Participants

Reaction Steps

(E)-methyl 3-methoxy-2-(2-((4-((E)-3-(dimethylamino)acryloyl)-2,5-dimethylphenoxy)-methyl)phenyl)acrylate (0.11 g, 0.25 mmol) obtained in Step 1 was reacted with 17 mg (1.5 eq) of methylhydroxyamine in 10 mL of methanol at room temperature for 3 hours with stirring, and then the reaction solvent was removed at a reduced pressure. The residue was stirred in water (20 mL), and the aqueous layer was extracted twice with 30 mL of dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and concentrated in a vacuum. Purification by chromatography afforded (E)-methyl 3-methoxy-2-(2-((2,5-dimethyl-4-(1-methyl-1H-pyrazol-3-yl)phenoxy)methyl)phenyl)acrylate as a white solid (75 mg, yield: 74%).

Provenance & Evidence