Hydrochloric Acid → HCID 68902596, compound

Participants

Reaction Steps

To a solution of 8-pyrimidin-2-yl-1,4-dioxa-spiro[4,5]decane-8-carbonitrile (220 mg, 0.897 mmol) in THF (1.3 mL) was added 25% aqueous NaOH (2.3 mL) and MeOH (1.3 mL). After being refluxed for 5.5 h, the reaction was cooled, adjusted to pH 7 (3 N aqueous HCl, ˜5 mL), and extracted (3×EtOAc). The combined organics were dried (Na2SO4) and concentrated under reduced pressure to provide crude 8-pyrimidin-2-yl-1,4-dioxa-spiro[4,5]decane-8-carboxylic acid as a white solid.

Provenance & Evidence