HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-Amino-4-hydroxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-Hydroxy-3-nitrobenzonitrile | HCID 76758 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Amino-4-hydroxybenzonitrile | HCID 271258 | 73.3% |
Reaction Steps
A mixture of 4-hydroxy-3-nitrobenzonitrile (100 mg, 0.61 mmol), palladium on charcoal (10 mg, 10%), EtOH (0.67 mL) and ethyl acetate (0.33 mL) was hydrogenated at rt for 2 h. Then the mixture was filtered and concentrated to give 3-amino-4-hydroxybenzonitrile 60 mg (73%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772285B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-58b0e9def0334536bc2c2035a073a008 |
| Source note | uspto-grants-2014_07 |