Dimethylformamide → HCID 58574671, compound

Participants

Reaction Steps

The mixture of 7-bromo-2-(chloromethyl)-3-methylquinazolin-4(3H)-one (125 mg, 0.43 mmol), pyrrolidine (65 mg, 0.91 mmol), K2CO3 (244 mg, 1.768 mmol) and DMF (10 mL) was stirred at room temperature for 30 min. Then water was added and the mixture was extracted with ethyl acetate (3×10 mL). The combined organic layers were washed with brine (3×10 mL), dried over Na2SO4, filtered and evaporated to give 100 mg of the desired product. MS (ESI): 322, 324 (MH+).

Provenance & Evidence