Piperidine → HCID 58574691, compound

Participants

Reaction Steps

A solution of (9H-fluoren-9-yl)methyl 6′-bromo-9′-oxo-3′,9′-dihydro-1′H-spiro[piperidine-4,2′-pyrrolo[2,1-b]quinazoline]-1-carboxylate (0.6 g, 1.1 mmol, 1 equiv) and piperidine (4 mL) in DCM (50 mL) was stirred at room temperature overnight. The reaction mixture was then diluted with water and extracted with ethyl acetate (3×100 mL). The combined organic layers were dried over Na2SO4. After filtration and concentration, the residue was purified by silica gel chromatography to give the desired product.

Provenance & Evidence