HCID 58574731, compound → HCID 58574663, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-bromo-6H-pyrido[2,1-b]quinazoline-8,11(7H,9H)-dione (0.04 g, 1.37 mmol, 1 equiv) in dry THF was added CH3MgBr (0.27 mL, 2.74 mmol, 2 equiv) dropwise at 0° C. The resulting mixture was stirred for 4 h at 0° C. The reaction was quenched with saturated NH4Cl, extracted with EtOAc, and dried over Na2SO4. The organic extract was concentrated under reduced pressure to give the desired product. MS (ESI): 309, 311 (MH+).

Provenance & Evidence