Potassium Hydroxide → HCID 58574149, compound

Participants

Reaction Steps

To a solution of 9-((trimethylsilyl)ethynyl)-3,4-dihydro-1H-pyrazino[2,1-b]quinazolin-6(2H)-one (120 mg) in MeOH (50 mL) was added 1 N KOH (2 mL). The mixture was stirred at room temperature for 1 h. Then the reaction mixture was adjusted pH to 8 and extracted with ethyl acetate three times. The combined organic layers were dried over Na2SO4 and concentrated to give the desired product (60 mg), which was purified by column chromatography. MS (ESI): 226 (MH+).

Provenance & Evidence