Methyl iodide → HCID 58574303, compound

HRID 1619333Notes

Reaction equation

HRID 1619333 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:16])[N:7]3[CH2:15][CH2:14][NH:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1.[CH3:17]I>CC(C)=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:16])[N:7]3[CH2:15][CH2:14][N:13]([CH3:17])[CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 58574180HCID 58574180, compound

Product 1

HCID 58574303HCID 58574303, compoundYield 62.2%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 9-bromo-3,4-dihydro-1H-pyrazino[2,1-b]quinazolin-6(2H)-one (200 mg, 0.71 mmol, 1 equiv) and MeI (101 mg, 0.71 mmol, 1 equiv) in acetone (35 mL) was stirred at room temperature for 2 h. Then the reaction mixture was then concentrated and purified by column chromatography to give 130 mg of the desired product. MS (ESI): 294/296 (MH+).

Workup

  1. concentrationThen the reaction mixture was then concentrated
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-5858655920de486c871767585fd1f707
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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