Potassium Carbonate → HCID 58574299, compound

Participants

Reaction Steps

A solution of 7-bromo-2-(chloromethyl)-3-(piperidin-2-ylmethyl)quinazolin-4(3H)-one and K2CO3 (1 g, 7.2 mmol) in CH3CN was stirred at reflux for 1.5 h. After it was cooled to room temperature, the mixture was diluted with H2O (30 mL) and extracted with ethyl acetate (3×50 mL). The combined organic layers were dried over Na2SO4, and the crude product was purified by column chromatography to give the desired product. MS (ESI): 334, 336 (MH+).

Provenance & Evidence