2,2-Dimethyl-1,3-propanediamine → 9-bromo-3,3-dimethyl-3,4-dihydro-1H-pyrimido[2,1-b]quinazolin-6(2H)-one

Participants

Reaction Steps

A mixture of (E)-methyl-4-bromo-2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)benzoate (0.1 g, 0.27 mmol) and 2,2-dimethylpropane-1,3-diamine (28 mg, 0.27 mmol) in dry THF was stirred for 2 h at room temperature, then the solvent was evaporated to give the crude product, which was purified by column chromatography to give 80 mg of the title compound. MS (ESI): 308, 310 (MH+).

Provenance & Evidence