Methoxymethyl-triphenylphosphonium chloride → HCID 58574510, compound

Participants

Reaction Steps

To a solution of (methoxymethyl)triphenylphosphonium chloride (171 mg, 0.5 mmol, 1 equiv) in 5 mL THF at −78° C. was added n-BuLi (0.2 mL, 0.5 mmol, 1 equiv) dropwise and stirred at the same temperature for half an hour. A solution of 3-((3-fluorophenyl)ethynyl)-6,7,9,10-tetrahydroazepino[2,1-b]quinazoline-8,12-dione (173 mg, 0.5 mmol, 1 equiv) in THF was then added to the mixture dropwise at the same temperature and stirred for 2 hours. Then the reaction mixture was quenched with water and extracted with ethyl acetate (3×20 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure to give the desired product, which was purified by silica gel chromatography. MS (ESI): 375 (MH+).

Provenance & Evidence