Triethylamine → HCID 58574295, compound

Participants

Reaction Steps

To a stirred solution of 3-bromo-8-hydroxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one (290 mg, 0.938 mmol) and excess Et3N in DCM (10 mL) was added Ms-Cl (0.76 mL). The mixture was stirred for 1.5 h at room temperature. Then the reaction mixture was diluted with water and extracted with EtOAc (3×50 mL). The combined organic layers were dried over Na2SO4. After filtration and concentration, the crude product was directly used for the next step. MS (ESI): 387, 389 (MH+).

Provenance & Evidence