Potassium Hydroxide → HCID 58574276, compound

Participants

Reaction Steps

A solution of 3-((trimethylsilyl)ethynyl)-9,10-dihydro-6H-spiro[azepino[2,1-b]quinazoline-8,2′-[1,3]dioxolan]-12(7H)-one (1.5 g, 4.1 mmol, 1 equiv) and 1 N aq. KOH in methanol was stirred at rt for half an hour. The reaction mixture was quenched with water and extracted with ethyl acetate (3×100 mL). The combined organic layers were washed with brine and dried over anhydrous sodium sulfate, then concentrated under reduced pressure. The product was obtained by silica gel chromatography purification.

Provenance & Evidence