2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[2-(methoxycarbonyl)-(1H)-indol-6-yl]-4-pyrimidineamine

HRID 161937Notes

Reaction equation

HRID 161937 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([Cl:8])[n:7]1.[NH2:10][c:11]1[cH:12][cH:13][c:14]2[cH:15][c:16]([C:20](=[O:21])[O:22][CH3:23])[nH:17][c:18]2[cH:19]1>>[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([NH:10][c:11]2[cH:12][cH:13][c:14]3[cH:15][c:16]([C:20](=[O:21])[O:22][CH3:23])[nH:17][c:18]3[cH:19]2)[n:7]1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 22060206Methyl 6-amino-1H-indole-2-carboxylate

Product 1

HCID 220603902-chloro-5-fluoro-N4-[2-(methoxycarbonyl)-(1H)-indol-6-yl]-4-pyrimidineamine

Sources & evidence

ORD record
ord-a9852d26d0924616b6be8347737edec8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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