Ethanol → HCID 58574406, compound

Participants

Reaction Steps

8-((3-fluorophenyl)ethynyl)-3-vinyl-4H-pyrido[1,2-a]pyrimidin-4-one (30 mg, 0.1 mmol) was added into a saturated HO/ethanol (5 mL) solution. After stirring at ambient temperature for 3 h, the solution was adjusted to pH=8 and extracted with ethyl acetate (3×50 mL). The combined organic layers were dried over Na2SO4 and concentrated to give the crude product, which was purified by column chromatography. MS (ESI): 309 (MH+); 1H NMR (300 MHz, CDCl3) δ 9.01-8.99 (d, J=7.44 Hz, 1H), 8.38 (s, 1H), 7.77 (s, 1H), 7.45-7.39 (m, 2H), 7.33-7.28 (m, 1H), 7.20 (m, 1H), 7.17 (m, 1H), 5.11-5.02 (m, 1H), 3.54-3.52 (d, J=6.03 Hz, 1H), 2.62-2.57 (d, J=6.6 Hz, 3H). mGluR5 PAM EC50: ++. Fold shift at 10 μM: +.

Provenance & Evidence