HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl malonate → 1,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl malonate | HCID 7943 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Product | 1,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioate | HCID 593603 | 98.7% |
Reaction Steps
A solution of dimethyl malonate (5 g, 37.9 mmol, 1 equiv) in DMF-DMA (11.3 g, 94.8 mmol, 2.5 equiv) was stirred at room temperature overnight. Then the reaction mixture was concentrated to give 7 g of the desired product, which was directly used for the next step without further purification. MS (ESI): 188 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772301B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-7434af8fe5bc478882cbb6e406ca2e18 |
| Source note | uspto-grants-2014_07 |