p-Toluenesulfonic acid → HCID 67258003, compound

Participants

Reaction Steps

A solution of sodium (2-oxodihydrofuran-3(2H)-ylidene)methano-late (134 mg, 1 mmol), 4-bromopyridin-2-amine (173 mg, 1.0 mmol) and 4-methylbenzenesulfonic acid (50 mg, 0.29 mmol) in toluene was stirred at 150° C. for 1 hr. After the suspension was diluted with water, the solution was adjusted to pH 8 and extracted with ethyl acetate. Then, the organic layers were dried over Na2SO4 and concentrated to give crude product, which was used for then next reaction without further purification. MS (ESI): 269, 271 (MH+).

Provenance & Evidence