Hydrochloric Acid → HCID 18992356, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-bromo-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one (200 mg, 0.21 mmol, 1.0 equiv) and excess zinc powder, HCl (37%, 1 mL) in MeOH (4 mL) was stirred at 75° C. for 30 min. The reaction mixture was poured into water (50 mL) and extracted with ethyl acetate (3×20 mL). The combined organic layer was concentrated under reduced pressure. The residue was purified by silica gel chromatography to give the desired product. MS (ESI): 279, 281 (MH+).

Provenance & Evidence