Water → 5-Methoxy-2,3,6,7-tetrahydro-1,4-oxazepine

A solution of 1,4-oxazepan-5-one (1 g, 8.7 mmol) and (CH3)3O+BF4− (1.9 g, 12.8 mmol) in DCM (30 mL) was stirred at room temperature for 20 h. The reaction mixture was then poured into water (60 mL) and extracted with DCM (2×50 mL). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate. After filtration and concentration, the crude product was used for the next step without further purification.

1. extractionextracted with DCM (2×50 mL)
2. washThe combined organic layers were washed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationAfter filtration and concentration
5. customthe crude product was used for the next step without further purification

ORD record

ord-44802bd349044a509bbb1013d050773c

Source dataset

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08772301B2