HCID 58574211, compound → HCID 58574193, compound

HRID 1619425Notes

Reaction equation

HRID 1619425 reaction equation
[CH2:1]=[C:2]1[C:9]2=[N:10][C:11]3[C:16]([C:17](=[O:18])[N:8]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1)=[CH:15][CH:14]=[C:13]([C:19]([OH:21])=[O:20])[CH:12]=3.[H][H]>CO.[Pd]>[CH3:1][CH:2]1[C:9]2=[N:10][C:11]3[C:16]([C:17](=[O:18])[N:8]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1)=[CH:15][CH:14]=[C:13]([C:19]([OH:21])=[O:20])[CH:12]=3

Participants

5

Reactant 2

HCID 58574211HCID 58574211, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58574193HCID 58574193, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6-methylene-13-oxo-7,8,9,10,11,13-hexahydro-6H-azocino[2,1-b]quinazoline-3-carboxylic acid (50 mg) was dissolved in MeOH (5 mL). To the mixture was added a catalytic amount of Pd/C. The reaction mixture was vacuumed and then back filled with hydrogen gas three times. After completion, the reaction was filtered and washed with methanol. The filtrate was concentrated to give the desired product. MS (ESI): 287 (MH+).

Workup

  1. filtrationAfter completion, the reaction was filtered
  2. washwashed with methanol
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-c64bec6299154284ba0bd630cb672ad1
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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