反应详情

温度

27 °C

To a solution of 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole (500 mg, 0.0095 moles) in acetone (10 ml) conc. HCl (3 ml) was added portion-wise and reaction mixture was stirred for 2 hours at 27° C. The reaction mixture was concentrated and residue was dissolved in ethyl acetate. The organic extract was successively washed with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 360 mg product as white solid.

1. customportion-wise and reaction mixture
2. concentrationThe reaction mixture was concentrated
3. dissolutionresidue was dissolved in ethyl acetate
4. extractionThe organic extract
5. washwas successively washed with water & brine
6. dry with materialdried over sodium sulfate
7. customevaporated under reduced pressure