HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1619443Generated: November 1, 2026
4,6-Dichloro-5-methylpyrimidine → 4-Chloro-5-methyl-6-(1-(pyrimidin-2-yl)piperidin-4-yloxy)pyrimidine
https://huagongshe.com/reaction/1619443
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4,6-Dichloro-5-methylpyrimidine | HCID 818860 | — |
| Reactant | 1-(Pyrimidin-2-yl)piperidin-4-ol | HCID 20234098 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Chloro-5-methyl-6-(1-(pyrimidin-2-yl)piperidin-4-yloxy)pyrimidine | HCID 86665163 | 3.3% |
Reaction Steps
Potassium tert-butoxide (2.86 gm, 0.01397 moles) was added to an ice-cold solution of 1-(pyrimidin-2-yl)piperidin-4-ol (2.50 gm, 0.01397 moles) and 4,6-dichloro-5-methylpyrimidine (2.27 mg, 0.01397 moles) in dry THF (15 ml) and the reaction mixture was stirred for 5 hours at 30° C. The reaction mixture was poured into ice cold water, solid precipitated was filtered and dried under vacuum to obtain 140 mg of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772302B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-52999f5c34234070939fbe00122f346c |
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| Source note | uspto-grants-2014_07 |
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