反应详情

温度

27 °C

To a solution of 4-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methyl-6-(1-(pyrimidin-2-yl)piperidin-4-yloxy)pyrimidine (1.5 gm, 0.0031 moles) in acetone (20 ml) conc. HCl (2 ml) was added portion-wise and the reaction mixture was stirred for 3 hours at 27° C. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The organic extract was successively washed with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 700 mg product as white solid

1. concentrationThe reaction mixture was concentrated
2. dissolutionthe residue was dissolved in ethyl acetate
3. extractionThe organic extract
4. washwas successively washed with water & brine
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure