HCID 86675896, compound → HCID 178432269, compound

Participants

Reaction Steps

A mixture of 0.63 g I.11 (N-acetyl-N-(2,4-dinitro-6-trifluoromethyl-phenyl)-acetamide) and 0.2 g Pd/C 10% in 20 ml glacial acetic acid was stirred for 5 h at 80° C. under a pressure of hydrogen of 50 psi. The catalyst was filtered and the solvent was evaporated. To the residue, 30 ml glacial acetic acid were added and the mixture was stirred for 2 h at reflux. The solvent was removed. The residue was treated with 50 ml 4 N aqueous hydrochloric acid and stirred for 1 h at reflux. The reaction mixture was cooled down to ambient temperature and the pH was adjusted to ˜7 with potassium carbonate. The resulting precipitate was filtered, washed with 30 ml water and dried.

Provenance & Evidence