Butyric Acid → HCID 71257519, compound

Participants

Reaction Steps

To a solution (1.5 ml) of Y516 (60 mg, 0.098 mmol) produced in Example 35 in dimethylformamide were added n-butanoic acid (butyric acid) (20 μl, 0.02 mmol), HBTU (N,N,N′,N′-tetramethyl-O— (benzotriazol-1-yl)uronium Hexafluorophosphate) (40 mg, 0.1 mmol) and DIEA (N,N-diisopropylethylamine) (30 ml, 0.18 mmol), and the mixture was stirred at room temperature for 18 hr. Then, the reaction mixture was cooled, poured into cold water, and extracted with chloroform. The obtained chloroform extract was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent; chloroform:methanol (40:1)) to give the title compound (Y639) (44 mg, 77%).

Provenance & Evidence