HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butanal → 1-propyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butanal | HCID 261 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | L-Tryptophan | HCID 6305 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-propyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid | HCID 3161832 | 58% |
Reaction Steps
L-tryptophan (5.10 g, 25 mmol), water (300 ml), H2SO4 (0.5M, 50 ml), n-butyraldehyde (10 ml) and ethanol (100 ml) were added in a 250 ml round-bottom flask, and then stirred and reacted at room temperature for 24 h. After filtration, wash with water and drying, white solids (3.75 g, 58%) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772311B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-412de87610234ca8bc04e06223598e84 |
| Source note | uspto-grants-2014_07 |