Acetic Acid → HCID 25227444, compound

Participants

Reaction Steps

To a solution of 20 mg of (±)-{2-chloro-8-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[3,2-b]indolizin-5-yl}-acetic acid methyl ester in 1.2 mL of THF was added 1.5 mL of water, followed by 0.2 mL of 1 N aqueous LiOH solution. The mixture was stirred for 1 h at room temperature and 0.1 mL of AcOH was added, followed by 3 mL of brine. The mixture was extracted with 2×10 mL of EtOAc and the combined extracts was dried over Na2SO4 and concentrated to give 18 mg of the desired product as a white solid.

Provenance & Evidence