Acetic Acid → HCID 59471427, compound

Participants

Reaction Steps

To a solution of (±)-{8-[(4-fluoro-benzenesulfonyl)-methyl-amino]6,7,8,9-tetrahydro-pyrido[3,2-b]indolizin-5-yl}-acetic acid methyl ester (28 mg) in 4 mL of 121 THF/water was added 0.2 mL of 1 N aqueous LiOH solution. After stirring for 1 h at room temperature, AcOH (0.2 mL) and 4 mL of brine were added and the mixture was extracted with 2×10 mL of EA, dried over Na2SO4. After filtration and concentration, the residue was purified by silica gel chromatography eluted with 50% EtOAc/hexane containing 5% AcOH to give 20 mg of the desired product as a white solid.

Provenance & Evidence