HCID 10125600, compound → HCID 10236756, compound

HRID 1619499Notes

Reaction equation

HRID 1619499 reaction equation
F[C:2]1[CH:7]=[CH:6]C=C[C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:23]=[C:22]3[C:17]([CH:18]=[CH:19][CH:20]=[N:21]3)=[C:16]([NH:24][CH2:25][CH2:26][CH2:27][NH2:28])[N:15]=2)=[CH:10][CH:9]=1.COC1C=C(C2C=C3C(C=CC=N3)=C(NCCCN)N=2)C=C(OC)C=1OC.CC1C=C(C2C=C3C(C=CC=N3)=C(NCCCN)N=2)C=CC=1C.NCC(O)CNC1N=C(C2C=CC3C(=CC=CC=3)C=2)C=C2C=1C=CC=N2.NCC(O)CNC1N=C(C2C=CC(C3C=CC=CC=3F)=CC=2)C=C2C=1C=CC=N2.NCC(O)CNC1N=C(C2C=CC(C3C=CC(OC)=CC=3)=CC=2)C=C2C=1C=CC=N2.NCC(O)CNC1N=C(C2C=C(OC)C(OC)=C(OC)C=2)C=C2C=1C=CC=N2.NCC(O)CNC1N=C(C2C=CC(Br)=CC=2)C=C2C=1C=CC=N2.COC1C=CC(C2C=CC(C3C=C4C(C=CC=N4)=C(NCC(C)(C)CN)N=3)=CC=2)=CC=1.CN(C)C1C=CC(C2C=C3C(C=CC=N3)=C(NCC(O)C)N=2)=CC=1.CN(C)C1C=CC(C2C=C3C(C=CC=N3)=C(NCCSCCO)N=2)=CC=1>>[CH:10]1[C:9]2[C:8](=[CH:3][CH:2]=[CH:7][CH:6]=2)[CH:13]=[CH:12][C:11]=1[C:14]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][CH:20]=[N:21]2)=[C:16]([NH:24][CH2:25][CH2:26][CH2:27][NH2:28])[N:15]=1

Participants

12

Reactant 11

HCID 10125600HCID 10125600, compoundHCID 10126265HCID 10126265, compoundHCID 10126725HCID 10126725, compoundHCID 10172571HCID 10172571, compoundHCID 10173168HCID 10173168, compoundHCID 10215705HCID 10215705, compoundHCID 10215981HCID 10215981, compoundHCID 10236902HCID 10236902, compoundHCID 10237414HCID 10237414, compoundHCID 10309260HCID 10309260, compoundHCID 66736807HCID 66736807, compound

Product 1

HCID 10236756HCID 10236756, compound

Procedure

N-[7-(2′-fluoro[1,1′-biphenyl]-4-yl)-1,6-naphthyridin-5-yl]-1,3-propanediamine; N-[7-(3,4,5-trimethoxyphenyl)-1,6-naphthyridin-5-yl]-1,3-propanediamine; N-[7-(3,4-dimethylphenyl)-1,6-naphthyridin-5-yl]-1,3-propanediamine; 1-amino-3-[[7-(2-naphthalenyl)-1,6-naphthyridin-5-yl]amino]-2-propanol; 1-amino-3-[[7-(2′-fluoro[1,1′-biphenyl]-4-yl)-1,6-naphthyridin-5-yl]amino]-2-propanol; 1-amino-3-[[7-(4′-methoxy[1,1′-biphenyl]-4-yl)-1,6-naphthyridin-5-yl]amino]-2-propanol; 1-amino-3-[[7-(3,4,5-trimethoxyphenyl)-1,6-naphthyridin-5-yl]amino]-2-propanol; 1-amino-3-[[7-(4-bromophenyl)-1,6-naphthyridin-5-yl]amino]-2-propanol; N-[7-(4′-methoxy[1,1′-biphenyl]-4-yl)-1,6-naphthyridin-5-yl]-2,2-dimethyl-1,3-propanediamine; 1-[[7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl]amino]-2-propanol; 2-[[2-[[7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl]amino]ethyl]thio]-ethanol;

Sources & evidence

ORD record
ord-8cf963e700594d5db19e8ca1268ce4d8
Source dataset
uspto-grants-2014_07
Patent number
US08772298B2

Reaction notes

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