HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59343384, compound → (3R,3aR,6aR)-hexahydro-2H-furo[3,2-b]pyrrol-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59343384 | HCID 59343384 | — |
| Reactant | tert-butyl (3R,3aR,6aR)-3-hydroxy-hexahydro-2H-furo[3,2-b]pyrrole-4-carboxylate | HCID 66986914 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3R,3aR,6aR)-hexahydro-2H-furo[3,2-b]pyrrol-3-ol | HCID 55287552 | — |
Reaction Steps
Preparation of (3R,3aR,6aR)-(9H-fluoren-9-yl)methyl 3-hydroxytetrahydro-2H-furo[3,2-b]pyrrole-4(5H)-carboxylate (2b). Alcohol (2f) (558 mg, 2.43 mmol) was dissolved in 4M HCl in dioxane (14.06 mL) and left to stand at ambient temperature for 1 h. The solvent was removed in vacuo and the residue azeotroped from toluene (3×20 mL) to give hydrochloride salt of (3R,3aR,6aR)-hexahydro-2H-furo[3,2-b]pyrrol-3-ol (2 g) used directly in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737150B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-46b6e0c75d42419c97542f1bd2e16994 |
| Source note | uspto-grants-2010_06 |