HRID1619506

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID123440

Bromomethyl 2-methoxyphenyl ketone

C9H9BrO2

结构：CC(C)(C)OC(=O)NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1

HCID67425060

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1C(=O)C[N+]12CCC(CC1)[C@@H](OC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C2.[Br-]

HCID86665818

未命名化合物

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

2-Bromo-1-(2-methoxyphenyl)ethanone (45.8 mg, 0.20 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C1) (72.0 mg, 0.20 mmol) in acetonitrile (3 ml). The reaction was stirred at RT overnight. The product was collected by suction filtration to get (3R)-3-(2-(tert-butoxycarbonylamino)-2-phenylacetoxy)-1-(2-(2-methoxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide (112 mg; 95% yield).

WORKUP

后处理

filtrationThe product was collected by suction filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1bd5d609534c44dbbe138d1d89cc50f6
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08772314B2
来源说明: uspto-grants-2014_07

反应 SMILES

[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])=[O:4].[C:13]([O:17][C:18]([NH:20][CH:21]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:22]([O:24][C@@H:25]1[CH:30]2[CH2:31][CH2:32][N:27]([CH2:28][CH2:29]2)[CH2:26]1)=[O:23])=[O:19])([CH3:16])([CH3:15])[CH3:14]>C(#N)C>[Br-:1].[C:13]([O:17][C:18]([NH:20][CH:21]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:22]([O:24][C@@H:25]1[CH:30]2[CH2:31][CH2:32][N+:27]([CH2:2][C:3]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[O:11][CH3:12])=[O:4])([CH2:28][CH2:29]2)[CH2:26]1)=[O:23])=[O:19])([CH3:16])([CH3:14])[CH3:15]