Hydrochloric Acid → (R)-Quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride

Participants

Reaction Steps

To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C1) (1.25 g, 3.47 mmol) in THF (20 ml), was added 37% hydrogen chloride (2.00 ml, 24.3 mmol) dropwise. The reaction was stirred at RT for 15 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride (1.16 g; quantitative yield) as a solid. The compound was used in the next step without any further purification.

Provenance & Evidence