Phenacyl bromide → HCID 57345354, compound

Participants

Reaction Steps

To a solution of 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C58) (230 mg, 0.61 mmol) in DMF (15 ml) and acetonitrile (5 ml), was added 2-bromo-1-phenylethanone (134 mg, 0.68 mmol). The reaction was stirred at RT for 15 hours, and then the solvent was evaporated. The crude was first triturated with i-Pr2O and then purified by flash chromatography (DCM/MeOH=94/6) to obtain 3-(2-(tert-butoxycarbonylamino)-2-phenylacetoxy)-8-methyl-8-(2-oxo-2-phenylethyl)-8-azoniabicyclo[3.2.1]octane bromide (196 mg; 56% yield).

Provenance & Evidence