2-Bromo-1-(thiophen-2-yl)ethan-1-one → HCID 57344851, compound

Participants

Reaction Steps

To a solution of (R)-1-methylpyrrolidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C61) (170 mg, 0.51 mmol) in DMF (5 ml) and acetonitrile (3 ml), was added 2-bromo-1-(thiophen-2-yl)ethanone (115 mg, 0.56 mmol) and the reaction was stirred at RT for 15 hours. The solvent was evaporated, and the crude was purified by flash chromatography (DCM/MeOH=9/1) to obtain (3R)-3-(2-(tert-butoxycarbonylamino)-2-phenylacetoxy)-1-methyl-1-(2-oxo-2-(thiophen-2-yl)ethyl)pyrrolidinium bromide (132 mg; 48% yield).

Provenance & Evidence