Triethylamine → HCID 67605974, compound

Participants

Reaction Steps

(R)-quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride (I25) (110 mg, 0.33 mmol) was suspended in DCM (4 ml), and triethylamine (121 μl, 1.65 mmol) was added obtaining a solution. 3,4-difluorobenzene-1-sulfonyl chloride (53.1 μl, 0.40 mmol) was added, and the reaction was stirred at RT for 3 hours. The reaction was diluted with DCM and washed with water and brine. The organic phase was dried over Na2SO4, filtered and evaporated to dryness. The residue was triturated with Et2O to obtain (R)-quinuclidin-3-yl 2-(3,4-difluorophenylsulfonamido)-2-phenylacetate (40 mg; 28% yield), which was used as such in the next step.

Provenance & Evidence