Triethylamine → HCID 67606166, compound

Participants

Reaction Steps

(R)-quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride (I25) (116 mg, 0.35 mmol) was suspended in DCM (6 ml), and triethylamine (102 μl, 1.39 mmol) was added obtaining a clear solution. 2,4-Dimethylthiazole-5-sulfonyl chloride (88.0 mg, 0.42 mmol) was added, and the reaction was stirred at RT for 3 hours. The reaction was diluted with DCM and washed with water and brine. The organic phase was dried with Na2SO4, filtered and evaporated to dryness. The crude was purified by flash chromatography (DCM/MeOH=85/15) to obtain (R)-quinuclidin-3-yl 2-(2,4-dimethylthiazole-5-sulfonamido)-2-phenylacetate (67 mg; 44.2% yield).

Provenance & Evidence