Phenacyl bromide → HCID 86665852, compound

Participants

Reaction Steps

To a solution of (R)-quinuclidin-3-yl 2-(methylsulfonamido)-2-phenylacetate (C76) (38.9 mg, 0.11 mmol) in EtOAc (1 ml) and acetonitrile (0.5 ml), was added 2-bromo-1-phenylethanone (25.2 mg, 0.13 mmol). The mixture was stirred at RT for 2 hours, and then the solvent was evaporated. The crude was triturated with Et2O to obtain (3R)-3-(2-(methylsulfonamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (40 mg; 64.7% yield).

Provenance & Evidence