Phenacyl bromide → HCID 57345352, compound

Participants

Reaction Steps

To a solution of (R)-quinuclidin-3-yl 2-phenyl-2-(2,2,2-trifluoroethyl-sulfonamido)acetate (C78) (60 mg, 0.15 mmol) in EtOAc (2 ml), was added 2-bromo-1-phenylethanone (35.3 mg, 0.18 mmol). The reaction was stirred at RT for 16 hours. Then the solvent was evaporated, and the crude was purified by flash chromatography (DCM/MeOH=9/1) to obtain (3R)-1-(2-oxo-2-phenylethyl)-3-(2-phenyl-2-(2,2,2-trifluoroethylsulfonamido)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (5 mg; 6% yield).

Provenance & Evidence