Phenacyl bromide → HCID 57345350, compound

Participants

Reaction Steps

To a solution of (R)-quinuclidin-3-yl 2-phenyl-2-(phenylmethylsulfonamido)-acetate (C80) (41 mg, 0.10 mmol) in EtOAc (2 ml), was added 2-bromo-1-phenylethanone (21.7 mg, 0.11 mmol), and the reaction was stirred at RT for 1 hour. The solvent was evaporated, and the crude was triturated with Et2O to obtain (3R)-1-(2-oxo-2-phenylethyl)-3-(2-phenyl-2-(phenylmethylsulfonamido)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (50 mg; 82% yield).

Provenance & Evidence