Hydrochloric Acid → HCID 67606137, compound

Participants

Reaction Steps

To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(4-methoxyphenyl)acetate (C44) (560 mg, 1.43 mmol) in THF (20 ml), was added 37% hydrogen chloride (1.0 ml, 12.2 mmol). The reaction was stirred at RT for 15 hours. Then a second portion of 37% hydrogen chloride (1.0 ml, 12.2 mmol) was added, and the reaction was stirred at RT for additional 48 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-(4-methoxyphenyl)acetate dihydrochloride (521 mg; quantitative yield).

Provenance & Evidence