Hydrochloric Acid → HCID 67607082, compound

Participants

Reaction Steps

To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-p-tolylacetate (C41) (250 mg, 0.67 mmol) in THF (50 ml), was added 37% hydrogen chloride (1.0 ml, 12.2 mmol), and the reaction was stirred at RT for 15 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-p-tolylacetate dihydrochloride (232 mg; quantitative yield).

Provenance & Evidence